dianhydrogalactitol
A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest.
| Synonym: | bi-functional alkylating agent VAL-083 dianhydrodulcitol diepoxydulcitol diepoxygalactitol dulcitol diepoxide galactitol |
|---|---|
| Abbreviation: | DAG |
| Code name: | VAL-083 VAL083 |
| Chemical structure: | 1,2,5,6 dianhydrogalactitol 1,2:5, 6-diepoxydulcitol 1,2:5,6 dianhydrogalactitol 1,2:5,6-dianhydrodulcitol galactitol, 1,2:5,6-dianhydro- (8CI 9CI) |