diazoxide
A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells.
| US brand name: | Proglycem |
|---|---|
| Code name: | SRG-95213 |
| Chemical structure: | 3-methyl-7-chloro-1,2,4-benzothiadiazine 1,1-dioxide |
| NSC code: | 64198 76130 |