dideoxyadenosine
A synthetic nucleoside analogue of deoxyadenosine and a prodrug of didanosine in which the 3' hydroxyl group on the ribose moiety is replaced by a hydrogen atom. Dideoxyadenosine competitively inhibits adenylyl cyclase, thereby reducing levels of cyclic adenosine monophosphate (cAMP). By inhibiting cAMP-mediated gene activation in tumor cells, this agent may retard tumor cell proliferation.
| Abbreviation: | ddA |
|---|---|
| Chemical structure: | 2',3'-Dideoxyadenosine 6-Amino-9-(2''3'-dideoxy-beta-D-glycero-pentofuranosyl)purine |
| IND number: | 30971 |
| NSC code: | 4279 7332 95943 |