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dideoxyadenosine

A synthetic nucleoside analogue of deoxyadenosine and a prodrug of didanosine in which the 3' hydroxyl group on the ribose moiety is replaced by a hydrogen atom. Dideoxyadenosine competitively inhibits adenylyl cyclase, thereby reducing levels of cyclic adenosine monophosphate (cAMP). By inhibiting cAMP-mediated gene activation in tumor cells, this agent may retard tumor cell proliferation.

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Abbreviation:	ddA
Chemical structure:	2',3'-Dideoxyadenosine 6-Amino-9-(2''3'-dideoxy-beta-D-glycero-pentofuranosyl)purine
IND number:	30971
NSC code:	4279 7332 95943

dideoxyadenosine

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