diethylstilbestrol
DES; the acronym for diethylstilbestrol, a synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, DES inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.
| Synonym: | diethylstilbestrol dipropionate diethylstilbestrolum Sinestrol stilboestrol dipropionate |
|---|---|
| US brand name: | Acnestrol Cyren A Deladumone Diastyl Domestrol Estrobene Estrosyn Fonatol Makarol Milestrol Neo-Oestronol I Oestrogenine Oestromenin Oestromon Palestrol Stilbestrol Stilbetin Stilboestroform Stilboestrol Synestrin Synthoestrin Vagestrol |
| Foreign brand name: | Antigestil Apstil Boestrol Bufon Distilbene Estrogenine Estromenin Grafestrol Microest Oestromensyl Serral Sexocretin Sibol Stilboefral Stilkap |
| Abbreviation: | DES |
| Chemical structure: | (E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol 3,4-bis(p-hydroxyphenyl)-3-hexene 4,4'-dihydroxy-alpha,beta-diethylstilbene alpha,alpha'-diethylstilbenediol trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3 |
| IND number: | 5019 |
| NSC code: | 3070 |