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dihydro-5-azacytidine

A synthetic nucleoside analogue of deoxycytidine. Dihydro-5-azacytidine inhibits DNA methyltransferase, thereby interfering with abnormal DNA methylation patterns that are associated with genetic instability in some tumor cells. Inhibition of this enzyme may restore expression of tumor-suppressor genes and result in antitumor activity.
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Abbreviation:DHAC
Chemical structure:1,3,5-triazin-2(1H)-one, 4-amino-3, 6-dihydro-1-beta-D-ribofuranosyl monohydrochloride
5,6-dihydro-5-azacytidine HCl
5,6-dihydro-5-azacytidine hydrochloride
IND number:19672
NSC code:264880
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