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ditiocarb sodium

The sodium salt form of ditiocarb, an active metabolite of disulfiram, with potential antineoplastic and chemosensitizing activities. Upon administration, ditiocarb sodium may form a complex with copper (Cu), a metal that selectively accumulates in cancer cells. This complex may inhibit the nuclear factor-kB (NF-kB) pathway activated by tumor hypoxia, thereby inhibiting tumor cell growth. It may also reverse chemoresistance and enhance cytotoxicity of other chemotherapeutic agents.
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Synonym:sodium diethyldithiocarbamate
US brand name:Imuthiol
Chemical structure:diethylcarbamodithioic acid, sodium salt
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