Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

DNA interference oligonucleotide PNT2258

A liposomal formulation of the 24-mer oligonucleotide PNT100, with potential antineoplastic activity. PNT2258 targets and complements to untranscribed DNA sequence upstream of BCL2 promoters, thereby interfering with DNA replication and transcription of the BCL2 gene. This may promote and restore the apoptotic pathway in BCL2-overexpressing tumor cells. BCL2, an anti-apoptotic protein, is overexpressed in a wide variety of tumors.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:DNA interference drug PNT2258
US brand name:DNAi® drug PNT2258
Code name:PNT2258
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search