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donor-derived haploidentical IL-21-expanded natural killer cells

A population of ex-vivo human interleukin-21 (IL-21) expanded donor-derived human leukocyte antigen (HLA) haploidentical natural killer (haploNK) cells, with potential immunomodulating and antineoplastic activities. Upon administration in patients undergoing HLA-haploidentical hematopoietic cell transplantation, the donor-derived haploidentical IL-21-expanded NK cells target, lyse and destroy tumor cells. IL-21 promotes sustained ex vivo proliferation of human NK cells and enhances its cytotoxic activity.
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Synonym:allogeneic IL-21-expanded haploNKs
donor-derived haploidentical IL-21-expanded NKs
donor-derived IL-21 expanded NK cells
IL-21-treated HLA-haploidentical donor NK cells
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