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elliptinium acetate

Acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.
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US brand name:Celiptium
Abbreviation:9-HME
HME
NMHE
Chemical structure:9-hydroxy-2-methylellipticinium acetate
9-hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium acetate (salt)
N-2-methyl-9-hydroxyellipticinium acetate
NSC code:264137
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