elliptinium acetate
Acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.
| US brand name: | Celiptium |
|---|---|
| Abbreviation: | 9-HME HME NMHE |
| Chemical structure: | 9-hydroxy-2-methylellipticinium acetate 9-hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium acetate (salt) N-2-methyl-9-hydroxyellipticinium acetate |
| NSC code: | 264137 |