NCI Drug Dictionary

The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

elliptinium acetate
Acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name:Celiptium
Chemical structure:
  • 9-hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium acetate (salt)
  • 9-hydroxy-2-methylellipticinium acetate
  • N-2-methyl-9-hydroxyellipticinium acetate