Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

menin inhibitor DSP-5336

An orally bioavailable, small molecule inhibitor of menin, with potential antineoplastic activity. Upon oral administration, menin inhibitor DSP-5336 targets and binds to the nuclear protein menin, thereby preventing the interaction between the two proteins menin and menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) and the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a key role in the survival, growth, transformation and proliferation of certain kinds of leukemia cells.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:menin-MLL interaction inhibitor DSP-5336
Code name:DSP 5336
DSP-5336
DSP5336
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search