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estramustine phosphate sodium

The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects.
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Synonym:estramustine phosphate
estramustine sodium phosphate
US brand name:Emcyt
Foreign brand name:Estracyt
Code name:Leo-299
Ro-21-8837/001
Chemical structure:estra-1,3,5(10)-triene-3,17-diol(17(beta))-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt, monohydrate
estramustine 17-(dihydrogenphosphate) disodium salt
NSC code:89199
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