estramustine phosphate sodium
The orally available disodium salt, monohydrate, of estramustine phosphate, a synthetic molecule that combines estradiol and nornitrogen mustard through a carbamate link. Estramustine and its major metabolite estramustine bind to microtubule-associated proteins (MAPs) and tubulin, thereby inhibiting microtubule dynamics and leading to anaphase arrest in a dose-dependent fashion. This agent also exhibits anti-androgenic effects.
| Synonym: | estramustine phosphate estramustine sodium phosphate |
|---|---|
| US brand name: | Emcyt |
| Foreign brand name: | Estracyt |
| Code name: | Leo-299 Ro-21-8837/001 |
| Chemical structure: | estra-1,3,5(10)-triene-3,17-diol(17(beta))-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt, monohydrate estramustine 17-(dihydrogenphosphate) disodium salt |
| NSC code: | 89199 |