ethosuximide
A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures.
| US brand name: | Zarontin |
|---|---|
| Chemical structure: | 3-ethyl-3-methylpyrrolidine-2,5-dione |
| NSC code: | 64013 |