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floxuridine

A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis.
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Synonym:FdUrD
floxuridin
fluorodeoxyuridine
fluorouridine deoxyribose
fluoruridine deoxyribose
US brand name:FUDF
Abbreviation:5-FUDR
FDUR
FUdR
Code name:WR-138720
Chemical structure:1-(2-deoxy-beta-D-ribofuranosyl)-5-fluorouracil
2'-deoxy-5-fluorouridine
5-fluoro-2'-deoxy-beta-uridine
5-fluoro-2'-deoxyuridine
5-fluorodeoxyuridine
5-fluorouridine deoxyribose
IND number:947
NSC code:27640
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