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fluorine F 18 3F-PHPG

A radioconjugate containing a substrate of the norepinephrine transporter (NET), chromaffin granule amine transporter (CGAT; vesicular monoamine transporter 1; VMAT1; VAT1; solute carrier family 18 member 1; SLC18A1) and synaptic vesicular amine transporter (SVAT; vesicular monoamine transporter 2; VMAT2; VAT2; solute carrier family 18 member 2; SLC18A2) labeled with the positron-emitting radioisotope fluorine F 18, with potential diagnostic imaging applications upon positron emitting tomography (PET)/computed tomography (CT). Upon administration, fluorine F 18 3F-PHPG is taken up by NET, VMAT1 and VMAT2 and accumulates in adrenergic tissues. This may allow for the visualization of tumors expressing these transporters upon PET/CT. NET, VMAT1 and/or VMAT2 are expressed in some adrenergic tumors.
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Synonym:[18F]3F-PHPG
3-[18F]fluoro-para-hydroxyphenethylguanidine
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