fluorine F 18 trioxolane

A labile iron pool (LIP) radiotracer composed of 1,2,4-trioxolane (TRX) radiolabeled with the positron-emitting isotope fluorine F 18, with potential cancer cell imaging activity during positron emission tomography (PET). As tumor cells accumulate more iron than normal, healthy cells due to their increased need for energy to proliferate, when fluorine F 18 TRX is administered, it is selectively taken up by rapidly proliferating tumor cells, reacts with ferrous iron (Fe2+), and accumulates in tumor cells. Upon PET, tumor cells.