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Gadoxetate Disodium

A paramagnetic contrast agent consisting of the disodium salt of the gadolinium ion chelated with the lipophilic moiety ethoxybenzyl (EOB) bound to diethylenetriamine pentaacetic acid (DTPA). When placed in a magnetic field, gadolinium produces a large magnetic moment and so a large local magnetic field, which can enhance the relaxation rate of nearby protons; as a result, the signal intensity of tissue images observed with magnetic resonance imaging (MRI) may be enhanced. Because this agent is preferentially taken up by normal functioning hepatocytes, normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced. In addition, because this agent is excreted in the bile, it may be used to visualize the biliary system using MRI.
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Synonym:Gadolinium EOB DTPA
Gadolinium Ethoxybenzyl Diethylenetriamine Pentaacetic Acid
Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid
Gadoxetic Acid Disodium
gadoxetic acid, disodium
US brand name:Eovist
Foreign brand name:EOB Primavist
Primovist
Abbreviation:Gd-(S)-EOB-DTPA
Gd-EOB-DTPA
Code name:ZK 139834
Chemical structure:(4S)-4-(4-ththoxylmethyl)-3,6,9-tris(carboxylatomethyl)-3,6,9-triazaundecanedoic acid, gadolinium complex, disodium salt
Disodium (N-((2S)-2-(bis(carboxymethyl)amino)-3-(p-ethoxyphenyl)propyl)-N-(2-(bis(carboxymethyl)amino)ethyl)glycinato(5-))gadolinate(2-)
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