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gallium Ga 68-DOTA-MGS5

A radioconjugate consisting of the minigastrin analog, MGS5, conjugated, via the bifunctional, macrocyclic chelating agent 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic acid (DOTA), to the radioisotope gallium Ga 68, with potential use as a tracer for cholecystokinin receptor subtype 2 (CCK2R)-epressing tumor cells during positron emission tomography (PET)/computed tomography (CT). Upon intravenous administration, gallium Ga 68-DOTA-MGS5 targets and binds to tumor cells expressing CCK2R and these cells can be detected upon PET/CT imaging. CCK2R is expressed on a variety of tumor cell types, such as medullary thyroid carcinoma (MTC), and gastroenteropancreatic and bronchopulmonary neuroendocrine tumors (NETs).
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Synonym:68Ga-DOTA-MGS5
68Ga-DOTA-minigastrin analog MGS5
68Ga-labeled minigastrin analogue MGS5
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