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gallium Ga 68 FAP-2286

A radioconjugate composed of FAP-2286, a fibroblast activation protein (FAP)-targeted peptide, attached to a linker and tetraazacyclododecane tetraacetic acid chelator, conjugated to the radioisotope gallium Ga 68, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission tomography (PET). Upon administration of gallium Ga 68 FAP-2286, the FAP-2286 moiety targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected during PET imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME).
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Synonym:68Ga-FAP-2286
gallium-68 labelled FAP-2286
gallium-68-FAP-2286
Code name:FAP 2286
FAP2286
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