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gallium Ga 68 FF58

A radiopharmaceutical agent comprised of FF58, a non-arginine-glycine-aspartic acid (Arg-Gly-Asp/RGD) small molecule targeting the transmembrane receptors integrin alpha V beta 3 (avb3) and 5 (avb5), labeled with gallium Ga 68, with potential avb3/5 imaging activity during positron emission topography (PET)/computed tomography (CT). After intravenous administration of gallium Ga 68 FF58, the FF58 moiety selectively targets and binds to avb3/5 on the tumor cell membrane. Upon PET/CT imaging, avb3/5-expressing tumor cells can be visualized and their expression levels can be quantified. avb3/5, members of the integrin receptor family, are overexpressed on certain tumor cells and tumor endothelial cells while minimally or not expressed on healthy, normal cells; they play key roles in angiogenesis, tumor proliferation and survival.
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Synonym:[68Ga]-FF58
68Ga-FF58
gallium Ga 68-FF58
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