gallium Ga 68 FF58

A radiopharmaceutical agent comprised of FF58, a non-arginine-glycine-aspartic acid (Arg-Gly-Asp/RGD) small molecule targeting the transmembrane receptors integrin alpha V beta 3 (avb3) and 5 (avb5), labeled with gallium Ga 68, with potential avb3/5 imaging activity during positron emission topography (PET)/computed tomography (CT). After intravenous administration of gallium Ga 68 FF58, the FF58 moiety selectively targets and binds to avb3/5 on the tumor cell membrane. Upon PET/CT imaging, avb3/5-expressing tumor cells can be visualized and their expression levels can be quantified. avb3/5, members of the integrin receptor family, are overexpressed on certain tumor cells and tumor endothelial cells while minimally or not expressed on healthy, normal cells; they play key roles in angiogenesis, tumor proliferation and survival.