gallium Ga 68-labeled RM2
A radioconjugate containing a synthetic bombesin receptor antagonist targeting the gastrin-releasing peptide receptor (GRPR), that is linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68 GRPR antagonist BAY86-7548, the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells can then be visualized. GRPR, also called bombesin receptor 2 (BB2), is a G protein-coupled seven-transmembrane receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers.
| Synonym: | (68)Ga-DOTA-4-amino-1-carboxymethylpiperidine-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 [68Ga]-labeled bombesin analog BAY86-7548 [68Ga]RM2 68-Ga RM2 68Ga-bombesin antagonist BAY86-7548 68Ga-DOTA RM2 68Ga-DOTA-bombesin analog BAY86-7548 Ga-68-labeled bombesin antagonist BAY 86-7548 gallium Ga 68-labeled GRPR antagonist BAY86-7548 gallium Ga68-labeled GRPR antagonist RM2 |
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| Code name: | BAY 86-7548 |