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gallium Ga 68-labeled RM2

A radioconjugate containing a synthetic bombesin receptor antagonist targeting the gastrin-releasing peptide receptor (GRPR), that is linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68 GRPR antagonist BAY86-7548, the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells can then be visualized. GRPR, also called bombesin receptor 2 (BB2), is a G protein-coupled seven-transmembrane receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers.
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Synonym:(68)Ga-DOTA-4-amino-1-carboxymethylpiperidine-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2
[68Ga]-labeled bombesin analog BAY86-7548
[68Ga]RM2
68-Ga RM2
68Ga-bombesin antagonist BAY86-7548
68Ga-DOTA RM2
68Ga-DOTA-bombesin analog BAY86-7548
Ga-68-labeled bombesin antagonist BAY 86-7548
gallium Ga 68-labeled GRPR antagonist BAY86-7548
gallium Ga68-labeled GRPR antagonist RM2
Code name:BAY 86-7548
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