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gallium Ga 68-NOTA-hGZP

A radiotracer composed of hGZP, a biotinylated human granzyme B peptide, conjugated with the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) and labeled with the radionuclide gallium Ga 68, with potential imaging activity using positron emission tomography (PET). Upon administration, the hGZP moiety of gallium Ga 68-NOTA-hGZP targets and binds to granzyme B, a cytotoxic serine protease released by cytotoxic T lymphocytes (CTLs), in tumors. Upon PET imaging, tumoral granzyme B expression can be visualized, and CTL activation and activity can be assessed.
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Synonym:[68Ga]-NOTA-hGZP
68Ga-NOTA-hGZP
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