Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

gallium Ga 68-NOTA-Sgc8

A radioconjugate consisting of Sgc8, a 41 oligonucleotides long single-stranded DNA aptamer and protein tyrosine kinase-7 (PTK7; colon carcinoma kinase-4; CCK4)-targeting ligand, linked via the bi-functional agent 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), to the beta-emitting radioisotope gallium Ga 68, with potential imaging activity during positron emission topography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-Sgc8, the Sgc8 aptamer moiety targets and binds to PTK7 expressed on certain tumor cells. Upon PET/CT imaging, this radioconjugate can be used to detect and quantify PTK7-expressing tumor cells. PTK7, a member of the receptor tyrosine kinase (RTK) superfamily, is overexpressed in many different tumor cell types and plays an important role in tumor cell proliferation, migration and invasion.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:[68Ga]-Sgc8
68Ga-labeled ssDNA aptamer Sgc8
Abbreviation:68Ga-Sgc8
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search