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gallium Ga 68 R8760

A radioconjugate composed of a melanocortin 2 receptor (MC2R; adrenocorticotropic hormone receptor; ACTHR)-binding ligand, conjugated to the radioisotope gallium Ga 68, with potential use as a tracer for MC2R-expressing tumors during positron emission tomography (PET). Upon administration of gallium Ga 68 R8760, the MC2R-targeting moiety targets and binds to MC2R-expressing tumor cells. Upon binding, MC2R-expressing tumor cells can be detected during PET imaging. MC2R, a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors, plays a key role in adrenal steroidogenesis and is overexpressed in adrenocortical carcinoma.
Synonym:68Ga-R8760
gallium Ga 68-R8760
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