ganciclovir
A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation.
| Synonym: | BW 759U BW-B759U Nordeoxyguanosine |
|---|---|
| Foreign brand name: | Cymevan Virgan |
| Abbreviation: | 2'NDG BW-B759U DHPG |
| Chemical structure: | 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one 2'-Nor-2'-deoxyguanosine 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine |