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gimeracil

A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines.
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Synonym:chlorodihydroxypyridine
Abbreviation:CDHP
Chemical structure:5-chloro-2,4-dihydroxypyridinediol
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