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giredestrant

An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, giredestrant specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.
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Synonym:selective estrogen receptor degrader GDC-9545
selective estrogen receptor downregulator GDC-9545
SERD GDC-9545
Code name:GDC 9545
GDC-49545
RG6171
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