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glucarpidase

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A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor.

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Synonym:	carboxypeptidase-G2
US brand name:	Voraxaze
Abbreviation:	CPDG2 CPG2
IND number:	4663
NSC code:	641273

glucarpidase

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