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golimumab

A human monoclonal antibody directed against the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-a) with immunosuppressive activity. Golimumab binds to TNF-a, thereby preventing TNF-a-mediated immune responses. TNF-a production is dysregulated in various auto-immune diseases and in cancer.
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Synonym:immunoglobulin G1, anti-(human Tumor Necrosis Factor Alpha) (human monoclonal CNTO 148 gamma-1-chain), disulfide with human monoclonal CNTO 148 kappa-chain, dimer
Code name:CNTO 148
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