gusperimus
A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines.
| Synonym: | deoxyspergualin Deoxyspergualin Hydrochloride Gusperimus Trihydrochloride |
|---|---|
| Foreign brand name: | Spanidin |
| Abbreviation: | DSG |
| Code name: | BMS-181173 BMY-42215-1 NKT-01 |
| Chemical structure: | 1-amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione 15-deoxyspergualin hydrochloride 7-{(aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amnio]-1-hydroxy-2-oxoethyl]heptanamide N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl]hydroxymethyl]-7-guanidinoheptanamide |
| IND number: | 28053 |
| NSC code: | 356894 |