Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

HER2 mutant-selective inhibitor NVL-330

An orally bioavailable mutant-selective inhibitor of the receptor tyrosine kinase human epidermal growth factor receptor 2 (HER2), with potential antineoplastic activity. Upon oral administration, HER2 mutant-selective inhibitor NVL-330 targets, binds to, and inhibits the activity of HER2 oncogenic alterations, including HER2 exon20 insertion mutations (exon20ins), HER2 activating point mutations, and amplified wild-type HER2. This prevents HER2-mediated signaling and may lead to cell death in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase overexpressed on a variety of tumor cell types, plays an important role in tumor cell proliferation and tumor vascularization. NVL-330 is able to penetrate the blood-brain-barrier (BBB).
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:HER-2 mutant-selective inhibitor NVL-330
Code name:NVL 330
NVL-330
NVL330
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search