idoxuridine
An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is incorporated into DNA and disrupts viral replication. Upon oral administration of the idoxuridine prodrug ropidoxuridine and hepatic conversion by aldehyde oxidase into idoxuridine, this agent incorporates into DNA and sensitizes cells to ionizing radiation by increasing DNA strand breaks.
| Synonym: | 1beta-D-2'-Deoxyribofuranosyl-5-iodouracil 2'-deoxy-5-iodouridine 5-iododeoxyuridine 5-IUdR IDU uracil, 5-iodo-1-(2-deoxy-beta-D-ribofuranosyl)- uridine, 2'-deoxy-5-iodo- |
|---|---|
| US brand name: | Dendrid Herplex Stoxil |
| Foreign brand name: | Idexur Idoxene Idulea Iduridin Kerecid Virudox |
| Abbreviation: | IDUR IdURD IUdR |
| Code name: | SKF 14287 |
| Chemical structure: | 1-(2-deoxy-beta-D-ribofuranosyl)-5-iodouracil 2'-deoxy-5-iodouridine 5-iodo-2'-deoxyuridine |
| IND number: | 22475 934 |
| NSC code: | 39661 |