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ifosfamide

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A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes.
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Synonym:Ifomide
Iphosphamid
iphosphamide
Iso-Endoxan
Isoendoxan
isophosphamide
Naxamide
US brand name:Ifex
Foreign brand name:Holoxan
Holoxane
IFO-Cell
Ifolem
Ifomida
Ifoxan
Mitoxana
Tronoxal
Abbreviation:IFF
IFO
IFX
IPP
Code name:Asta Z-4942
MJF-9325
Z-4942
Chemical structure:2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine
3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide
N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
IND number:7887
NSC code:109724
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