IKZF2 protein degrader DKY709

A low molecular weight (MW) degrader of the protein IKZF2 (Helios), with potential immunomodulating and antineoplastic activities. Upon administration, IKZF2 protein degrader DKY709 modulates the E3 (ubiquitin) ligase and allows for the interaction between the E3 ubiquitin ligase substrate receptor and its target protein IKZF2, thereby targeting IKZF2 for ubiquitination. This induces proteasome-mediated degradation of IKZF2, which is a transcriptional repressor in T cells, and modulates the activity of the immune system. This may induce the activation of T-lymphocytes and the induction of T-cell-mediated anti-tumor immune responses. IKZF2, a zinc finger transcription factor expressed on the majority of regulatory T cells (Tregs) and a member of the Ikaros transcription factor family, plays a key role in cancer immune signal transduction and immunosuppression.