inalimarev
A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1 (mucin-1), a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of the three co-stimulatory molecule transgenes B7-1, ICAM-1 and LFA-3. Upon administration, inalimarev may enhance CEA and MUC-1 presentation to antigen presenting cells (APC) and may activate a cytotoxic T lymphocyte (CTL) response against CEA- and MUC-1-expressing tumor cells.
| Synonym: | recombinant vaccinia-CEA-MUC1-TRICOM vaccine recombinant vaccinia-CEA(D609)/MUC1(L93)/TRICOM vaccine rVaccinia-CEA(D609)/MUC1(L93)/TRICOM vaccine vaccinia-CEA-MUC-1-TRICOM vaccine |
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| US brand name: | PANVAC-V |
| Abbreviation: | vCEA-MUC-1-TRI |