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incyclinide

A chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
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US brand name:Metastat
Code name:CMT-3
COL 3
Chemical structure:4-dimethlyamino sancycline
4-dimethlyaminosancycline
6-deoxy, 6-demethyl, 4-de-dimethylamino tetracycline
IND number:54600
NSC code:683551
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