indium In 111-ABD147

A radioimmunoconjugate consisting of ABD147, an antibody fragment directed against the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) conjugated to the radioisotope indium In 111 (111In), with potential imaging activity. Upon administration of indium In 111-ABD147, ABD147 targets and binds to DLL3 on DLL3-expressing tumor cells. Upon uptake and imaging, DLL3-expressing tumor cells can be visualized. This allows the assessment of DLL3 expression on tumor cells as well as tumor uptake of the agent. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.