indium In 111-XYIMSR-01

A radioconjugate consisting of XYIMSR-01, a bivalent low molecular weight ligand targeting two separate sites on carbonic anhydrase IX (CAIX), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with indium In 111 (111In), with potential imaging activity during single photon emission computed tomography (SPECT). Upon administration of indium In 111-XYIMSR-01, XYIMSR-01 targets and binds to CAIX-expressing tumor cells, followed by internalization and retention of the radioisotope. This allows for imaging of CAIX-expressing tumor cells upon SPECT. CAIX is overexpressed in various tumors and plays a key role in intra- and extracellular pH regulation, cancer cell progression, survival, migration and invasion.