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indoximod

A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
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Synonym:1-methyl-d-tryptophan
D-(+)-1-methyltryptophan
D-1MT
Abbreviation:1-MT
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