tri-specific NK cell engager CC-92328

A tri-specific natural killer (NK) cell engager, with potential immunomodulating and antineoplastic activities. Upon administration, the tri-specific NK cell engager CC-92328 binds to as of yet unelucidated proteins expressed on both cancer cells and NK cells, thereby bringing cancer cells and NK cells together. This stimulates the NKs and allows for NK-mediated cancer cell killing. In addition, the NKs activate T and B cells, and enhance a cytotoxic T-lymphocyte (CTL) immune response against cancer cells.