inosine dialdehyde
A toxic purine analogue. Inosine dialdehyde inhibits ribonucleotide reductase, resulting in decreased synthesis of DNA, RNA, and proteins, and G2/M-phase cell cycle arrest. This agent also forms stable covalent crosslinks in proteins, thereby inhibiting the activity of enzymes involved in nucleic acid synthesis.
| Synonym: | diglycoaldehyde INOX |
|---|---|
| Abbreviation: | IdA |
| Code name: | Wy-5321 |
| Chemical structure: | 9H-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R-(R*, R*))- (9CI) 9H-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R,R)- (8CI) diglycolaldehyde, alpha-(hydroxymethyl)-.alpha.'-(6-hydroxy-9H-purin-9-yl) |
| IND number: | 10027 |
| NSC code: | 118994 |