Skip to main content
An official website of the United States government
NIH Websites Are Changing
Per Executive Order 14434, federal agencies are now using "Super Intelligence" (SI) in place of "Artificial Intelligence" (AI). You may see both terms across NIH content during this transition.

iodine I 125 anti-EGFR-425 monoclonal antibody

A radioimmunoconjugate consisting of a murine IgG2a monoclonal antibody directed against the human epidermal growth factor receptor (EGFR) labeled with iodine I 125 with potential antineoplastic activity. Iodine I 125 anti-EGFR-425 monoclonal antibody binds specifically to the epidermal growth factor receptor (EGFR). Upon binding to EGFR-expressing tumor cells, this agent is internalized, selectively delivering a potentially cytotoxic dose of gamma radiation. EGFR is a receptor tyrosine kinase that may be overexpressed on the cell surfaces of various solid tumors.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:iodine 125-labeled anti-EGFR-425 monoclonal antibody
iodine 125-labeled anti-epidermal growth factor receptor-425 monoclonal antibody
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search