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iodine I 131 iopofosine

A radioconjugate composed of iopofosine, a phospholipid ether analog, labeled with the radioactive isotope iodine I 131, with potential antineoplastic activity. Upon administration, iodine I 131 iopofosine selectively accumulates in and retains within tumor cells for a prolonged period of time due to the decreased activity of a phospholipase D (PLD) in tumor cells compared to normal cells, thereby delivering cytotoxic radiation specifically to tumor cells. PLD is an enzyme found in the cell membrane of normal cells that degrades phospholipids.
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Synonym:131I-CLR1404
131I-NM-404
CLR 1404 I-131
CLR-1404 I-131
CLR131
I-131 PLE analogue CLR1404
iopofosine I 131
NM-404 I-131
PDC CLR 131
phospholipid ether-drug conjugate CLR 131
Abbreviation:I-131-CLR1404
Code name:CLR 131
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