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ioflubenzamide I-131

An iodine 131-radiolabeled small-molecule benzamide compound with potential antineoplastic activity. The benzamide moiety of ioflubenzamide I-131 binds to melanin, selectively delivering a cyotoxic dose of gamma and beta radiation to melanin-expressing tumor cells. Melanin pigments, polymer derivatives of the amino acid tyrosine, are over-expressed in approximately 40% of melanomas.
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Synonym:131-I-MIP-1145
iodine I 131 MIP-1145
Chemical structure:N-(4-(2-(diethylamino)ethylcarbamoyl)-2-iodo-5-methoxyphenyl)benzo[d][1,3]dioxole-5 carboxamide; N-(2-diethylamino-ethyl)-4-(4-F-benzamido)-5-iodo-2-methoxy-benzamide
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