Skip to main content

Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

steroid sulfatase inhibitor BN 83495

An orally bioavailable tricyclic coumarin-based sulfamate with potential antineoplastic activity. Steroid sulfatase inhibitor BN 83495 selectively binds to and inhibits steroid sulfatase (STS), which may inhibit the production of locally active estrogens and so inhibit estrogen-dependent cell growth in tumor cells, such as those of the breast, ovary, and endometrium. STS is a cytoplasmic enzyme responsible for the conversion of circulating inactive estrone sulfate and estradiol sulfate to biologically active unconjugated estrone and estradiol, respectively.

Check for active clinical trials using this agent View this agent in the NCI Thesaurus

Abbreviation:	STS inhibitor BN 83495
Code name:	BN 83495 STX 64

steroid sulfatase inhibitor BN 83495

Search NCI's Drug Dictionary