isotretinoin
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
| Synonym: | 13-cis-retinoic acid 13-cis-vitamin A acid cis-retinoic acid isotretinoinum neovitamin A Neovitamin A Acid |
|---|---|
| US brand name: | Accutane Amnesteem Cistane Claravis Sotret |
| Foreign brand name: | Accure Isotrex Isotrexin Oratane Roaccutan Roaccutane Roacutan |
| Abbreviation: | 13-CRA |
| Code name: | Ro 4-3780 |
| Chemical structure: | 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)2cis-4-trans-6-trans-8-trans-nonatetraenoic Acid |
| IND number: | 28104 |
| NSC code: | 329481 |