isotretinoin
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
Synonym: | 13-cis-retinoic acid 13-cis-vitamin A acid cis-retinoic acid isotretinoinum neovitamin A Neovitamin A Acid |
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US brand name: | Accutane Amnesteem Cistane Claravis Sotret |
Foreign brand name: | Accure Isotrex Isotrexin Oratane Roaccutan Roaccutane Roacutan |
Abbreviation: | 13-CRA |
Code name: | Ro 4-3780 |
Chemical structure: | 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)2cis-4-trans-6-trans-8-trans-nonatetraenoic Acid |
IND number: | 28104 |
NSC code: | 329481 |