KDM4 inhibitor TACH101

An orally bioavailable, small-molecule, pan inhibitor of histone lysine (K) demethylase 4 (KDM4), with potential antineoplastic activity. Upon oral administration, KDM4 inhibitor TACH101 specifically targets, binds to and inhibits the catalytic activity of all members of the KDM4 family of proteins. This may prevent KDM4-mediated signaling, epigenetic dysregulation and inhibit the proliferation of tumor cells. The KDM4 family of histone demethylases is frequently upregulated in a variety of cancers and plays an important role in nuclear functions including the regulation of transcription, cell cycle, and DNA replication and repair.