ketoconazole
A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall.
| US brand name: | Nizoral Xolegel |
|---|---|
| Foreign brand name: | Fungarest Fungoral Ketoderm Ketoisdin Orifungal M Panfungol |
| Abbreviation: | KCZ |
| Code name: | R-41400 |
| Chemical structure: | cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine |
| NSC code: | 317629 |