Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

KRAS G12D inhibitor QTX3046

An orally bioavailable allosteric inhibitor of the oncogenic KRAS substitution mutation G12D, with potential antineoplastic activity. Upon oral administration, KRAS G12D inhibitor QTX3046 specifically targets and noncovalently binds to KRAS G12D. This prevents KRAS G12D-mediated signaling and activation of downstream survival pathways. This leads to an inhibition of the growth of tumor cells that overexpress KRAS G12D. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell proliferation, invasion, and metastasis. QTX3046 inhibits both the GTP-bound (ON) and GDP-bound (OFF) state conformations of KRAS G12D, and is able to cross the blood-brain barrier (BBB).
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Code name:QTX 3046
QTX-3046
QTX3046
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search