Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

lead Pb 203-VMT01

A radioconjugate composed of the melanocyte-stimulating hormone receptor (MSHR; melanocortin-1 receptor; MC1R; melanin-activating peptide receptor; melanotropin receptor)-targeting peptide, VMT01, labeled with the radioisotope lead Pb 203, with potential imaging activity using single photon emission computed tomography (SPECT)/computed tomography (CT). Upon administration of lead Pb 203-VMT01, VMT01 targets and binds to MC1R-expressing tumor cells. Upon SPECT/CT imaging, MC1R-expressing tumor cells can be detected. MC1R, a G protein-coupled receptor expressed by melanocytes that binds to melanocortins, is involved in regulating mammalian skin and hair color. It is upregulated on the surface of metastatic melanoma cells.
Check for active clinical trials using this agentView this agent in the NCI Thesaurus
Synonym:[203Pb]-VMT01
[203Pb]VMT01
203Pb-DOTA-VMT-MCR1
lead Pb 203-DOTA-VMT-MCR1
Search NCI's Drug Dictionary
Please enter up to 30 characters for your search