lipegfilgrastim
A long acting glyco-pegylated recombinant form of human granulocyte colony-stimulating factor (G-CSF), with hematopoietic activity. Similar to G-CSF, lipegfilgrastim binds to and activates specific cell surface receptors, and stimulates neutrophil progenitor proliferation and differentiation. Therefore, this agent may prevent the duration and incidence of chemotherapy-induced neutropenia. Compared to filgrastim, lipegfilgrastim has a prolonged plasma half-life.
| Synonym: | pegylated granulocyte colony stimulating factor (human short isoform) O(sup 3.137)-((3,5-dideoxy-5-((N-((omega-methoxypoly(oxyethylene))carbonyl)glycyl)amino)-D- glycero-alpha-D-galacto-non-2-ulopyranosylonic acid)-(2->6)-2-(acetylamino)-2-deoxy-alpha-D- galactopyranosyl)-des-(37-39)-(1-methionine)human granulocyte colony-stimulating factor (G-CSF, pluripoietin) |
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| US brand name: | Lonquest Lonquex |
| Code name: | XM22 |
| Chemical structure: | poly(oxy-1,2-ethanediyl), alpha-hydro-omega-methoxy-, 133-ester with granulocyte colony-stimulating factor (methionyl,133-(O-(2-(acetylamino)-6-O-(N-((N- carboxyglycyl)amino)-alpha-neuraminosyl)-2-deoxy-alpha-D-galactopyranosyl)-L-threonine)) (human) |